Anetheron waited in the Twisting Nether, acting as emissary of Archimonde to Tichondrius. He was one of the dreadlords assigned to watch over the Lich King, and grew agitated when they began to suspect the Lich King of treachery and possibly becoming a threat to the Burning Legion. But Tichondrius was confident that, despite his obvious ulterior motives, the Lich King was still providing the tools they needed to make way for the invasion. In a meeting in the Twisting Nether, Tichondrius assured Anetheron that everything was still well in his control.
When Archimonde came to the world, Anetheron went with him, and served as a personal guardsman. Anetheron showed his tenacity when he led the Scourge against the Sentinels, Alliance, and Horde in the final, climactic Battle of Mount Hyjal. He invaded the Great Alliance's base several times during the battle, calling infernals to serve him, with the objective of defeating the resistance so that Archimonde could ascend to crush the World Tree. However, Anetheron was killed either during or after the battle.