Perdition Hold[30, 63] is one of the two elite areas of the Maw. Before unlocking the area, players' Exposed Anima will leave them vulnerable to the locals:
Exposed Anima — Anima patterns reveal the player's vulnerabilities, increasing damage taken by 200% while in Perdition Hold.
The mobs already hit hard, so the 200% buff can effectively one-shot most classes. Upon reaching Tentative standing with Ve'nari, she will provide the quest  Rule 5: Be Audacious. This quest will shield the player's anima, allowing them to get around the area (and earn the achievement [Prepare for Trouble!]).